| 11 | Alpha Flight (1st Series) | 1st appearance of Diamond Lil (full); 1st appearance of Wild Child (full); 1st appearance of Box (full); 1st appearance of Flashback (full); 1st appearance of Omega Flight; Origin of Sasquatch |
| 11/NS | Alpha Flight (1st Series) | 1st appearance of Box (full); 1st appearance of Diamond Lil (full); 1st appearance of Flashback (full); 1st appearance of Omega Flight; 1st appearance of Wild Child (full); Origin of Sasquatch |
| 110 | Alpha Flight (1st Series) | 1st Appearance of Omega Flight; 1st Appearance of Bile; 1st Appearance of Miss Mass; 1st Appearance of Sinew; 1st Appearance of Strongarm; 1st Appearance of Tech-Noir; 1st Appearance of Ska’r; 1st Appearance of Firebug; Infinity War Crossover, Book 10 |
| 110/NS | Alpha Flight (1st Series) | 1st Appearance of Bile; 1st Appearance of Firebug; 1st Appearance of Miss Mass; 1st Appearance of Omega Flight; 1st Appearance of Sinew; 1st Appearance of Ska’r; 1st Appearance of Strongarm; 1st Appearance of Tech-Noir; Infinity War Crossover, Book 10 |
| 1 | Civil War: The Initiative | 1st Appearance of Omega Flight; Civil War Epilogue |
| 1-2 | Civil War: The Initiative | 1st appearance of Omega Flight; Civil War Epilogue |
| 1/NS | Civil War: The Initiative | 1st Appearance of Omega Flight; Civil War Epilogue |
| 131 | Fantastic Four (Vol. 1) | 1st Appearance of Omega |
| 131 | Fantastic Four (UK Edition, Vol. 1) | 1st Appearance of Omega (the ultimate Alpha Primitive); Versus Maximus |
| 141 | Green Lantern (2nd Series) | 1st Appearance of Auron; 1st Appearance of Broot; 1st Appearance of Demonia; 1st Appearance of Harpis; 1st Appearance of Kalista; 1st Appearance of Omega Men; 1st Appearance of Primus |
| 141/NS | Green Lantern (2nd Series) | 1st Appearance of Auron; 1st Appearance of Broot; 1st Appearance of Demonia; 1st Appearance of Harpis; 1st Appearance of Kalista; 1st Appearance of Omega Men; 1st Appearance of Primus |
| 1 | Marvel Feature (1st Series) | 1st appearance of Omegatron; 1st appearance of Defenders; Death of Yandroth (physical body); Origin of Defenders; Giant-Size; Sub-Mariner reprint |
| 1/A | Marvel Feature (1st Series) | 1st appearance of Omegatron; 1st appearance of Defenders; Death of Yandroth (physical body); Origin of Defenders |
| 1 | Omega Force | 1st Appearance of Archetype; 1st appearance of Dual; 1st appearance of Flashback (Entity); 1st appearance of Karad the Godslayer; 1st appearance of Omega Force; 1st appearance of The Drakon; 1st appearance of The Earon Raider |
| 1 | Omega the Unknown | 1st appearance of James-Michael Starling; 1st appearance of Omega the Unknown (Model X32); Marvel Value Stamp Series B #58 |
| 1 | Powers of X | 1st Appearance of the Man-Machine Ascendancy (Earth-TRN753); 1st Appearance of Librarian (Earth-TRN753); 1st Appearance of Nimrod the Greater (Earth-TRN753); 1st Appearance of the Man-Machine Supremacy (Earth-TRN756); 1st Appearance of Nimrod the Lesser (Earth-TRN756); 1st Appearance of Omega Sentinel (Earth-TRN756); 1st Appearance of Theta Sentinel (Earth-TRN756); 1st Appearance of Post-Humans (race) (Earth-TRN753); 1st Appearance of Wolverine (Earth-TRN753); 1st Appearance of X-Men (Earth-TRN753); 1st Appearance of Cardinal (X-Men) (Earth-TRN753); 1st Appearance of Cylobel (Earth-TRN753); 1st Appearance of Rasputin IV (Earth-TRN753); 1st Appearance of X-Men (Earth-TRN756); 1st Appearance of Cardinal (X-Men) (Earth-TRN756); 1st Appearance of Cylobel (Earth-TRN756); 1st Appearance of Last Horsemen of Apocalypse (Earth-TRN756); 1st Appearance of Death (Xorn) (Earth-TRN756); 1st Appearance of Famine (Cypher) (Earth-TRN756); 1st Appearance of Pestilence (North) (Earth-TRN756); 1st Appearance of War (Wolverine) (Earth-TRN756); 1st Appearance of Percival (Earth-TRN756); 1st Appearance of Rasputin IV (Earth-TRN756); Includes packet of Krakoa Seeds; Crossover Miniseries with House of X; Part 2 of 12; Story continued from House of X #1; Story continues in House of X #2 |
| 314/A | Spawn | 1st Appearance of Omega Spawn |
| 314/B | Spawn | 1st Appearance of Omega Spawn |
| 314/C | Spawn | 1st Appearance of Omega Spawn |
| 19 | Transformers, The | 1st appearance of Omega Supreme |
| 19/NS | Transformers, The | 1st appearance of Omega Supreme |
| 19 | Transformers, The (Canadian Edition) | 1st appearance of Omega Supreme |
| 1 | True Believers: Annihilation—Omega the Unknown | Reprints material from Omega The Unknown #1; 1st appearance of Omega the Unknown (Model X32) |
| 69 | Ultimate Spider-Man and X-Men | Reprints Ultimate Spider-Man #86; Reprints Ultimate X-Men #74; 1st appearance of Silver Sable (Ultimate); 1st appearance of Damage Control (Ultimate); 1st appearance of Omega Red (Ultimate); Death of Magician (Ultimate); 48 pages |
| 4 | X-Men (2nd Series) | 1st Appearance of Omega Red; Versus Omega Red |
| 4-2 | X-Men (2nd Series) | 1st Appearance of Omega Red; Versus Omega Red; Marvel Legends Gambit action figure insert |
| 4/NS | X-Men (2nd Series) | 1st Appearance of Omega Red; Versus Omega Red |