| 2 | Angel (1st series) | Series continued from appearance in Four Color Comics; May-Jul issue |
| 6 | Annihilation: Conquest | Death of Praxagora; Final issue; 1st team appearance of the New Guardians of the Galaxy: Star-Lord, Rocket Raccoon, Quasar, Adam Warlock, Gamora, Drax the Destroyer and Groot. |
| 6/NS | Annihilation: Conquest | Death of Praxagora; 1st team appearance of the New Guardians of the Galaxy: Star-Lord, Rocket Raccoon, Quasar, Adam Warlock, Gamora, Drax the Destroyer and Groot.; Final issue |
| 1 | Bonanza | Series continued from appearances in Four Color Comics |
| 2 | Brain Boy | Series numbering continued from appearance in Four Color Comics |
| 2 | Cisco Kid, The | Series continued from appearance in Four Color Comics |
| 4 | Colt .45 | Series continued from appearances in Four Color Comics |
| 24 | Doctor Aphra (2nd Series) | 1st Team Appearance of the Darkseekers |
| 24/A | Doctor Aphra (2nd Series) | 1st Team Appearance of the Darkseekers |
| 24/B | Doctor Aphra (2nd Series) | 1st Team Appearance of the Darkseekers |
| 287 | Fantastic Four (Vol. 1) | Doctor Doom appearance; Invincible Man Appearance; Wasp Appearance |
| 305 | Fantastic Four (Vol. 1) | Crystal Rejoins the FF; Quicksilver Appearance; Kristoff Appearance; Doctor Doom Appearance |
| 311 | Fantastic Four (Vol. 1) | Black Panther Appearance; Doctor Doom Appearance |
| 314/MJ | Fantastic Four (Vol. 1) | Versus Belasco; Master Pandemonium appearance |
| 318/MJ | Fantastic Four (Vol. 1) | Versus Blastaar; Molecule Man Appearance; Doctor Doom Appearance; Volcana appearance |
| 373 | Fantastic Four (Vol. 1) | Silver Sable Appearance; Doctor Doom Appearance; Molecule Man Appearance; Aron The Watcher Appearance; Puppet Master Appearance; Daredevil appearance; Spider-Man appearance |
| 31/NS | Ghost Rider (Vol. 2) | Includes Poster, 1st Full Team appearance of Midnight Sons, 1st Full Appearance of The Caretaker, 1st Full Appearance of Meatmarket |
| 6 | Gunsmoke (Dell) | Series continued from appearances in Four Color Comics |
| 3 | I Love Lucy Comics | Series continued from appearances in Four Color Comics (2nd series); Photos of Lucy and Desi on inside front cover |
| 40 | Justice League (4th Series) | 1st team appearance of a“new breed of conquerors, genetically engineered super-powered strike team |
| 40/A | Justice League (4th Series) | 1st team appearance of a“new breed of conquerors, genetically engineered super-powered strike team |
| 2 | Kona | Numbering continued from appearance in Four Color Comics #1253 |
| 1 | Little Orphan Annie | Series continued from appearances in Four Color Comics |
| 150 | Marvel Comics Presents | 1st appearance of Jessie Drake, an empathic metamorph and the first transgender Marvel character; 1st appearance of Steel Raven, a mercenary; 1st cameo team appearance of New Genix; Typhoid Mary becomes Bloody Mary |
| 150/NS | Marvel Comics Presents | 1st appearance of Jessie Drake, an empathic metamorph and the first transgender Marvel character; 1st appearance of Steel Raven, a mercenary; 1st cameo team appearance of New Genix; Typhoid Mary becomes Bloody Mary |
| 158 | Marvel Comics Presents | 1st team appearance of Clan Destine, a family of mystics: Crimson Crusader, Imp, Hex, Wallop, Cuckoo, Argent, Newton aka Warlord |
| 158/NS | Marvel Comics Presents | 1st team appearance of Clan Destine, a family of mystics: Crimson Crusader, Imp, Hex, Wallop, Cuckoo, Argent, Newton aka Warlord |
| 3 | Powers of X | 1st team appearance of the Church of Ascendancy; Battle of Apocalypse vs. Nimrod; Crossover Miniseries with House of X; Part 5 of 12; Continued from Powers of X #2; Continues in House of X #3 |
| 1 | Smitty | Series continued from appearances in Four Color Comics |
| 2 | Spaceman (Dell) | Series continued from appearance in Four Color Comics #1253 |
| 4 | Spike and Tyke (M.G.M.’s…) | Series numbering continued from appearances in Four Color Comics |
| 27 | Stories of the West (Zane Grey’s…) | Series continues from appearances in Four Color Comics (2nd Series) |
| 49 | Sub-Mariner, The (Vol. 2) | Cindy Jones apppearance; Doctor Doom appearance |
| 16 | Woody Woodpecker (Walter Lantz…) | Series continued from appearances in Four Color Comics |
| 4 | Yogi Bear (Gold Key) | Series continued from appearances in Four Color Comics (2nd Series) |