| 1 | 3-D Adventure Comics | 1st Appearance of Statman |
| 1 | 5-Cent Comics | 1st appearance of Dan Dare (Detective); Only two copies known to exist. |
| 1 | 15-Love | 1st appearance of Mill Collins |
| 4 | 22 Brides | 1st appearance of Painkiller Jane |
| 7 | 52 | 1st appearance Katherine Kane |
| 7/NS | 52 | 1st appearance Katherine Kane |
| 9 | 52 | 1st appearance of Batwoman (Kathy Kane); Indicia Says September 2006 |
| 9/NS | 52 | 1st appearance of Batwoman (Kathy Kane); Indicia Says September 2006 |
| 12 | 52 | 1st Appearance Isis (Adrianna Tomaz); Origin of Wonder Woman |
| 12/NS | 52 | 1st Appearance Isis (Adrianna Tomaz); Origin of Wonder Woman |
| 18 | 52 | 1st appearance of Daniel Jon Carter; Origin of Question (Vic Sage); Week Eighteen |
| 18/NS | 52 | 1st appearance of Daniel Jon Carter; Origin of Question (Vic Sage); Week Eighteen |
| 21 | 52 | 1st appearance Infinity Inc.; Death of Trajectory (Eliza Harmon) |
| 21/NS | 52 | 1st appearance Infinity Inc.; Death of Trajectory (Eliza Harmon) |
| 22 | 52 | 1st appearance Jon Standing Bear; Origin of Green Lantern |
| 22/NS | 52 | 1st appearance Jon Standing Bear; Origin of Green Lantern |
| 23 | 52 | 1st appearance of Osiris (Amon Tomaz); Origin of Wildcat (Ted Grant) |
| 23/NS | 52 | 1st appearance of Osiris (Amon Tomaz); Origin of Wildcat (Ted Grant) |
| 26 | 52 | 1st appearance of Sobek; Origin of Hawkgirl (Kendra Saunders); Origin of Hawkman (Carter Hall) |
| 26/NS | 52 | 1st appearance of Sobek; Origin of Hawkgirl (Kendra Saunders); Origin of Hawkman (Carter Hall) |
| 29 | 52 | 1st appearance of Jade (Nicki Jones) |
| 29/NS | 52 | 1st appearance of Jade (Nicki Jones) |
| 32 | 52 | 1st Appearance of Riddler’s Daughter; 1st Appearance of Son of Frankenstein; 1st Appearance of Talon; Origin of Blue Beetle (Jaime Reyes) |
| 32/NS | 52 | 1st Appearance of Riddler’s Daughter; 1st Appearance of Son of Frankenstein; 1st Appearance of Talon; Origin of Blue Beetle (Jaime Reyes) |
| 1/A | ’68 Jungle Jim | 1st appearance of Jungle Jim; Versus zombies |
| 4 | 100 Bullets | 1st Appearance of Augustus Medici; 1st Appearance of Megan Dietrich |
| 9 | 100 Bullets | 1st Appearance of Cole Burns; Cole Burns reactivated as Minutemen |
| 15 | 100 Bullets | 1st Appearance of Loop Hughes |
| 20 | 100 Bullets | 1st Appearance of Benito Medici |
| 21 | 100 Bullets | 1st Appearance of Jack Daw |
| 22 | 100 Bullets | 1st Appearance of Coochie |
| 23 | 100 Bullets | 1st Appearance of Crete; Disbanded Minutemen turn against the Trust |
| 24 | 100 Bullets | 1st Appearance of Mia Simone |
| 25 | 100 Bullets | 1st Appearance of Javier Vasco; 1st Appearance of Helena Kotias; 1st Appearance of Anwar Madrid; 1st Appearance of Fulvio Carlito; 1st Appearance of Axel Nagel; 1st Appearance of Sigmar Rhone; 1st Appearance of Joan D’Arcy |
| 26 | 100 Bullets | 1st Appearance of Echo Memoria |
| 27 | 100 Bullets | 1st Appearance of Milo Garrett |
| 28 | 100 Bullets | 1st Appearance of Wylie Times |
| 50 | 100 Bullets | 1st Appearance of Victor Ray |
| 69 | 100 Bullets | 1st Appearance of Roland Dietrich; Death of Axel Nagel |
| 70 | 100 Bullets | 1st Appearance of Lars Nagel; 1st Appearance of Anna Nagel; 1st Appearance of Remi Rome |
| 87 | 100 Bullets | 1st Appearance of Will Slaughter |
| 8/A | 1001 Arabian Nights: The Adventures of Sinbad | 1st Appearance of Osmium |
| 1 | 2000 A.D. | 1st Appearance of John Probe; 1st Appearance of Tharg; Origin of John Probe; Includes space spinner |
| 1/A | 2000 A.D. | 1st Appearance of John Probe; 1st Appearance of Tharg; 1st appearance of Tharg; Origin of John Probe; Missing space spinner |
| 2 | 2000 A.D. | 1st Appearance of Chief Judge Goodman; 1st Appearance of Judge Alvin; 1st Appearance of Judge Dredd; 1st Appearance of Whitey; 1st appearance of Judge Alvin; 1st appearance of Judge Dredd; 1st appearance of Whitey; Death of Judge Alvin; Includes biotronic stickers |
| 10 | 2000 A.D. | 1st Appearance of Call-Me-Kenneth; 1st Appearance of Walter the Wobot; 1st appearance of Walter the Wobot |
| 29 | 2000 A.D. | 1st appearance of Judge Giant; 1st appearance of Judge Griffin |
| 30 | 2000 A.D. | 1st Appearance of Rico (Judge Dredd’s clone brother); Dredd’s name revealed as Joe |
| 86 | 2000 A.D. | 1st Appearance of Judge Caligula |
| 149 | 2000 A.D. | 1st Appearance of Judge Death |
| 150 | 2000 A.D. | 1st Appearance of Judge Anderson (full) |
| 161 | 2000 A.D. | 1st Appearance of Judge Hershey |
| 167 | 2000 A.D. | 1st Appearance of Nemesis |
| 206 | 2000 A.D. | 1st Appearance of Chopper |
| 228 | 2000 A.D. | 1st Appearance of Rogue Trooper |
| 317 | 2000 A.D. | 1st Appearance of D.R. & Quinch |
| 376 | 2000 A.D. | 1st Appearance of Halo Jones |
| 457 | 2000 A.D. | 1st Appearance of Judge Silver |
| 500 | 2000 A.D. | 1st Appearance of Bad Company; 500th anniversary issue |
| 727 | 2000 A.D. | 1st Appearance of Judge Joyce |
| Anl 1981 | 2000 A.D. | 1st Appearance of Judge Dredd (in full-color story) |
| 8 | 2001, A Space Odyssey | 1st appearance of Mister Machine (Aaron Stack); Origin of Mister Machine (Aaron Stack) |
| 8/A | 2001, A Space Odyssey | 1st Appearance of Machine Man (as Mister Machine) |
| 8 | 2001, A Space Odyssey (UK Edition) | 1st appearance of Mister Machine (Aaron Stack); Origin of Mister Machine (Aaron Stack) |
| 1 | 2099 A.D. Genesis | 1st appearance of Fantastic Four 2099; 1st appearance of X-Nation 2099; 1st Appearance of X-Nation 2099; 1st Appearance of X-Nation 2099 and Fantastic Four 2099 |
| 1 | 2099 Unlimited | 1st appearance of Hulk 2099 (John Eisenhart) |
| 1/NS | 2099 Unlimited | 1st appearance of Hulk 2099 (John Eisenhart); Bullpen Bulletins: characterization; FF movie; Spiderman 2099 vs. Mutagen; Unlimited - letters on 2099 books; Wedding |
| 2 | 2099 Unlimited | 1st Appearance of R Gang 2099; Return of Hulk 2099 |
| 2/NS | 2099 Unlimited | 1st Appearance of R Gang 2099; Return of Hulk 2099 |
| 5 | 2099 Unlimited | 1st appearance of Hazzard 2099; Origin of Duke Stratosphere |
| 5/NS | 2099 Unlimited | 1st appearance of Hazzard 2099; Origin of Duke Stratosphere |
| 6 | 2099 Unlimited | 1st appearance of Galahad 2099 |
| 6/NS | 2099 Unlimited | 1st appearance of Galahad 2099 |
| 9 | 2099 Unlimited | 1st Appearance of Steel Rain |
| 9/NS | 2099 Unlimited | 1st Appearance of Steel Rain |