| Y*2*K: The Comic | NEC | 1999 |
| YAC 24-Hour Comic | Young American | 2002-2004 |
| Yagi the Bookshop Goat | Tokyopop | 2022 |
| Yagyu Ninja Scrolls | Del Rey | 2007-2008 |
| Yahgz | Papercutz | 2023 |
| Yahoo | Fantagraphics | 1988-1992 |
| Yaiba: Ninja Gaiden Z | Dark Horse | 2014 |
| Yaiba: Samurai Legend | Viz | 2025 |
| Yakari | Cinebook | 2005 |
| Yakitate!! Japan | Viz | 2006-present |
| Yakky Doodle and Chopper | Gold Key | 1962 |
| Yakuza | Eternity | 1987-1988 |
| Yakuza and His Omega, The: Raw Desire | Steamship | 2024 |
| Yakuza and His Omega: Raw Desire, The | Seven Seas | 2025 |
| Yakuza Cafe | Digital Manga | 2011 |
| Yakuza Demon Killers | IDW | 2016-2017 |
| Yakuza Fiancé | Seven Seas | 2023 |
| Yakuza Lover | Viz | 2021 |
| Yakuza Reincarnation | Seven Seas | 2022 |
| Yakuza Reincarnation (Kazé) | Kazé | 2021-2022 |
| Yakuza Rising | Red Cat Tales | |
| Yakuza’s Bias | Kodansha | 2023 |
| Yalek (Rossel) | Rossel | |
| Yamada Kun and The Seven Witches | Kodansha | 2015-present |
| Yamara | Steve Jackson Games | 1994 |
| Yama Yama/The Ugly Head | George DiCaprio | 1981 |
| Yamba | Editora Sol | 1959-1965 |
| Yam: Bite-Size Chunks | Top Shelf | 2008 |
| Yambo | Zinco | 1986-1988 |
| Yampa (Lug) | Editions Lug | 1973-1974 |
| Yan | Titan | 2025 |
| Yanagida & Mizuno | Magic | 2015 |
| Yang | Charlton | 1973-1976, 1985-1986 |
| Yang Gang | Keenspot | 2020 |
| Yankee | Alternative | 2015 |
| Yankee Comics | Remington Morse | 1941-1943 |
| Yankee Doodle: The Spirit of Liberty | Barbour Christian | 1988 |
| Yankee Girl | AC | 2003 |
| Yankee Girl: Stars & Stripes Forever | AC | 2012 |
| Yankee JK Kuzuhana-Chan | Akita Shoten | 2020-Present |
| Yankees Championship Challenge | Ultimate Sports | 2001 |
| Yanks in Battle | Quality | 1956 |
| Yaoi Hentai | Yaoi | 2005 |
| Yardbirds | Ziff-Davis | 1952 |
| Yarichin Bitch Club | Sublime | 2020 |
| Yarn Man | Kitchen Sink | 1989 |
| Yarns of Yellowstone | World Color | 1972 |
| Yars’ Revenge | Atari | 1982 |
| Yars Rising | IDW | 2024 |
| Yashahime: Princess Half-Demon | Viz | 2022 |
| Yasmeen | Scout | 2020 |
| Yataca | Mon Journal | 1968 |
| Yata Momo | Kuma | 2024 |
| Y-Att Chronicles, the | Eclipse Studio | 2009 |
| Yattering and Jack, The | Eclipse | 1991 |
| Yawn | Parody | 1992 |
| YDC (Yeah Dude Comics) | Yeah Dude | 2014 |
| Yeah! | DC | 1999–2000 |
| Yeah Baby | Avalon | 2000 |
| Yeah, I Drew It! | Broadsword | 2006-2007 |
| Yeah, It Is! | Leslie Stein | 2003 |
| Yeah Kou Phobia | Rewind Records | 2006 |
| Yearbook Stories: 1976-1978 | Top Shelf | 2007 |
| Year in Review: Spider-Man | Marvel | 2000 |
| Yearning Fox Lies in Wait, The | Kodansha | 2024 |
| Year of Marvels, A: The Amazing | Marvel | 2016 |
| Year of Marvels, A: The Incredible | Marvel | 2016 |
| Year of Marvels, A: The Unbeatables | Marvel | 2016 |
| Year of Marvels, A: The Uncanny | Marvel | 2016 |
| Year of Marvels, A: The Unstoppable | Marvel | 2016 |
| Year of the Creature | Creature | 2012 |
| Year of the Goat | SpellBound | 2015-Present |
| Year of the Goat: Pestilence | SpellBound | 2020 |
| Year of the Monkey (Aaron Warner’s…) | Image | 1997 |
| Year of the Rabbit | Drawn and Quarterly | 2019 |
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